Glutathione
Clinical evidenceThe body's own master antioxidant, often sold for skin whitening, where the real story is route, delivery, and overclaimed wellness endpoints.
What it is
Glutathione is a natural tripeptide your body makes from three amino acids: glutamate, cysteine, and glycine. Every cell produces it, and it sits inside cells at high concentration as the body's primary internal antioxidant and a key player in how the liver neutralizes and clears toxins.
How it works
It acts as a sponge for corrosive free radicals, protects other antioxidants like vitamins C and E, and helps liver enzymes attach to unwanted substances so they can be flushed out. The challenge is delivery: a plain oral dose has poor absorption, and different forms, pills, liposomal versions, and IV drips, get the molecule into the body in very different ways.
What people report
- ✦The body's main internal antioxidant, supporting every tissue
- ✦Supports the liver's phase-two detoxification system
- ✦Daily oral or liposomal forms can raise measured body stores in small studies
- ✦Researched for antioxidant status, immune support, liver support, and skin brightness, among many uses
Typical use
Oral and liposomal versions are taken daily. IV sessions, common in wellness clinics, are occasional drips. No single validated protocol covers all the wellness uses.
Dosing reference
Oral and liposomal daily dosing can move biomarkers in small human studies, and IV dosing (often 250–1000 mg or more per session) raises levels quickly. There is no established dose validated for skin or anti-aging outcomes, so verify clinic protocols.
Reference only — not a recommendation. Verify via primary sources.
Watch for
Raising glutathione levels is not the same as proving better outcomes in healthy people. The strongest consumer claims, especially for IV skin lightening, outrun the outcome data, and regulators have repeatedly warned that efficacy, dosing, and safety for cosmetic IV use are not established.
Notes
The molecule is far broader than the whitening market that made it famous. Endogenous biology: absolutely real. Consumer outcome claims: mostly exceed what studies show.
Educational content — not medical advice.