NAD+
Clinical evidenceThe longevity industry's biggest seller is actually a coenzyme in every cell, and most of the IV-drip promise rests on thin evidence.
What it is
NAD+ is not a peptide at all. It is a coenzyme, a helper molecule found in every cell, discovered over a century ago. It is central to the reactions that produce your body's energy currency, ATP, and it feeds repair enzymes that tend damaged DNA and support longevity-related pathways. Its levels naturally drop about 50% between young adulthood and old age.
How it works
Picture NAD+ as the battery that cells drain to make energy and to run their repair machinery. When it runs low, energy and repair slow down. Supplementation aims to top the battery back up. The body mostly takes in precursor molecules that get converted into NAD+, which is why clinics and bottles focus on those precursors.
What people report
- ✦Oral precursor supplements reliably raise NAD+ levels in the blood
- ✦Some randomized trials report modest improvements in insulin sensitivity, muscle function, and aerobic capacity
- ✦Supports DNA repair and sirtuin pathways central to aging research
- ✦Popular as both an oral supplement and an IV treatment in longevity clinics
Typical use
Oral precursors are often taken daily at 250–1000 mg. IV sessions, the clinic format, are typically 250–1000 mg per drips, often weekly or as one-off sessions.
Dosing reference
Oral NMN and NR at 250–1000 mg daily reliably raise circulating NAD+. IV NAD+ at 250–1000 mg per session is clinic dosing. There is no established IV dose validated by rigorous trials, so verify clinic protocols carefully.
Reference only — not a recommendation. Verify via primary sources.
Watch for
Raising blood NAD+ is proven. Everything after that is uncertain. No human study has shown lifespan or healthspan extension, and the IV format specifically, which costs hundreds per session, has almost no controlled trial support. One 2026 comparison even found IV NAD+ triggered an inflammatory white-blood-cell response that the oral precursor did not.
Notes
NAD+ biology is real and better documented than most longevity compounds. Still, the strongest evidence comes from cheap oral pills, not the expensive drip that dominates the market.
Reconstitution math for NAD+
Typical vial: 500mg dissolved in 3ml BAC water. Adjust to see the math.
Reconstitution Calculator
Understand the math — pick a peptide, see its info, and how reconstitution works.
BPC-157
Healing & recoveryThe repair peptide everyone in the gym talks about — powerful in rats, still unproven in humans.
BPC-157 is a short chain of 15 amino acids. It is not a natural hormone your body makes on its own. It was built in a lab as a fragment of a larger 'body protection compound' first found in human stomach juice in the 1990s. Vendors sell this engineered piece, not a natural sequence.
How it works (optional detail)
In animal studies, BPC-157 seems to nudge faster blood-vessel growth at injured spots, which is the body's first step in healing. It also appears to quiet inflammation. The idea is that by tickling repair pathways rather than ordering one single thing, it helps tendons, ligaments, and gut lining recover speedier than they would on their own.
Dosing reference: Common community dosing is a few hundred micrograms a day, usually injected near the site or into belly fat. There is no approved human dose.
Reconstitution math
Concentration: 166.667 mg/ml (500mg in 3ml)
To get 1mg, draw:
0.006 ml
≈ 1 units on a U-100 insulin syringe
This calculator shows how the arithmetic works using common vial sizes. It is an educational illustration — not a dosing recommendation. Always follow the specific product's instructions and verify with primary sources or a qualified professional.
Educational content — not medical advice.