Semaglutide
Clinical evidenceThe once-weekly GLP-1 that turned 'food noise' into a household phrase.
What it is
Semaglutide is a 31-amino-acid copy of a gut hormone called GLP-1, modified with two engineering tricks that let it survive digestion and last a full week in the body. You likely know its brand names: Ozempic, Wegovy, and the oral version Rybelsus. It is a drug a doctor prescribes, not a research supplement.
How it works
It tickles the GLP-1 receptor, a sensor your body already uses to manage appetite and blood sugar. The result: food moves out of the stomach more slowly, insulin comes out only when sugar is high, and the brain's hunger centers quiet down — which is the famous 'food noise' silencing.
What people report
- ✦Major, sustained weight loss when paired with lifestyle changes
- ✦Quiets intrusive food thoughts in many people
- ✦Lower risk of heart attacks and strokes in at-risk adults
- ✦Improves kidney outcomes and some fatty-liver cases
Typical use
It is used as a long-term chronic medication, not a short cycle. The dose climbs over several weeks, then stays steady while the person is on it.
Dosing reference
A once-weekly injection, with the exact dose set by a clinician. It must be prescribed — watch out for unregulated 'research' versions.
Reference only — not a recommendation. Verify via primary sources.
Watch for
Most of the lost weight returns within a year of stopping. Common side effects are stomach-related: nausea, vomiting, constipation. A 2026 trial did not show it slows Alzheimer's, so it is best thought of as a metabolic drug, not a brain drug.
Notes
The strongest-evidence peptide on this list — that is what a long list of phase-3 trials buys you. Around one in ten US adults has tried a GLP-1 by 2025.
Reconstitution math for Semaglutide
Typical vial: 5mg dissolved in 2ml BAC water. Adjust to see the math.
Reconstitution Calculator
Understand the math — pick a peptide, see its info, and how reconstitution works.
BPC-157
Healing & recoveryThe repair peptide everyone in the gym talks about — powerful in rats, still unproven in humans.
BPC-157 is a short chain of 15 amino acids. It is not a natural hormone your body makes on its own. It was built in a lab as a fragment of a larger 'body protection compound' first found in human stomach juice in the 1990s. Vendors sell this engineered piece, not a natural sequence.
How it works (optional detail)
In animal studies, BPC-157 seems to nudge faster blood-vessel growth at injured spots, which is the body's first step in healing. It also appears to quiet inflammation. The idea is that by tickling repair pathways rather than ordering one single thing, it helps tendons, ligaments, and gut lining recover speedier than they would on their own.
Dosing reference: Common community dosing is a few hundred micrograms a day, usually injected near the site or into belly fat. There is no approved human dose.
Reconstitution math
Concentration: 2.500 mg/ml (5mg in 2ml)
To get 1mg, draw:
0.400 ml
≈ 40 units on a U-100 insulin syringe
This calculator shows how the arithmetic works using common vial sizes. It is an educational illustration — not a dosing recommendation. Always follow the specific product's instructions and verify with primary sources or a qualified professional.
Educational content — not medical advice.