Tesamorelin
Clinical evidenceThe only GHRH analog with full FDA approval — and one of the few tools that targets deep belly fat on purpose.
What it is
Tesamorelin is a 44-amino-acid copy of growth hormone-releasing hormone (GHRH), modified to last long enough to be useful. It is sold as Egrifta and is FDA-approved for the belly fat buildup that happens in HIV-associated lipodystrophy. It is the only member of its class with a full approval behind it.
How it works
It tells the pituitary to pulse out growth hormone. That hormone tells the liver to make IGF-1, which in turn mobilizes visceral fat — the deep abdominal fat most tied to heart and metabolic trouble. A key detail: trials showed subcutaneous fat (the pinchable layer) mostly left alone while deep belly fat shrank.
What people report
- ✦Targets deep visceral belly fat specifically
- ✦Measured ~15-18% visceral fat reduction over six months
- ✦Some evidence of liver-fat and cognitive benefits in the studied group
- ✦Preserves the body's natural growth-hormone pulse rhythm
Typical use
Studied as daily injections for roughly 6-12 months. Peptide clinics often run longer on-again, off-again patterns, though that stretch isn't what the trials tested.
Dosing reference
Daily injection. Dose is fixed and the label is explicit that it is not a general weight-loss drug.
Reference only — not a recommendation. Verify via primary sources.
Watch for
IGF-1 roughly doubles on this drug and needs monitoring. The label states long-term cardiovascular safety is unknown. It is superb for visceral fat in the population studied; for general weight loss it is the wrong tool.
Notes
Fifteen-plus years of fixed approval in a narrow indication — a rare, honest signal of a clean mechanism.
Reconstitution math for Tesamorelin
Typical vial: 10mg dissolved in 2ml BAC water. Adjust to see the math.
Reconstitution Calculator
Understand the math — pick a peptide, see its info, and how reconstitution works.
BPC-157
Healing & recoveryThe repair peptide everyone in the gym talks about — powerful in rats, still unproven in humans.
BPC-157 is a short chain of 15 amino acids. It is not a natural hormone your body makes on its own. It was built in a lab as a fragment of a larger 'body protection compound' first found in human stomach juice in the 1990s. Vendors sell this engineered piece, not a natural sequence.
How it works (optional detail)
In animal studies, BPC-157 seems to nudge faster blood-vessel growth at injured spots, which is the body's first step in healing. It also appears to quiet inflammation. The idea is that by tickling repair pathways rather than ordering one single thing, it helps tendons, ligaments, and gut lining recover speedier than they would on their own.
Dosing reference: Common community dosing is a few hundred micrograms a day, usually injected near the site or into belly fat. There is no approved human dose.
Reconstitution math
Concentration: 5.000 mg/ml (10mg in 2ml)
To get 1mg, draw:
0.200 ml
≈ 20 units on a U-100 insulin syringe
This calculator shows how the arithmetic works using common vial sizes. It is an educational illustration — not a dosing recommendation. Always follow the specific product's instructions and verify with primary sources or a qualified professional.
Educational content — not medical advice.